Novel Role of Base Excision Repair (ber) in Mediating Cisplatin Cytotoxicity*
نویسندگان
چکیده
CYTOTOXICITY* Anbarasi Kothandapani, Venkata Srinivas Mohan Nimai Dangeti, Ashley R. Brown, Lauren A. Banze, Xiao-Hong Wang, Robert W. Sobol and Steve M. Patrick 1. Department of Biochemistry and Cancer Biology, University of Toledo – Health Science Campus, Toledo, OH 43614 2. Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburg, PA 15213 3. University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, PA 15213, USA 4. Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15213 Running head: BER modulates cisplatin cytotoxicity Address correspondence to: Stephan Patrick, PhD, 3035 Arlington Ave, Toledo, OH 43614. Phone: 419383-4152; Fax: 419-383-6168; Email: [email protected]
منابع مشابه
Epistatic role of base excision repair and mismatch repair pathways in mediating cisplatin cytotoxicity
Base excision repair (BER) and mismatch repair (MMR) pathways play an important role in modulating cis-Diamminedichloroplatinum (II) (cisplatin) cytotoxicity. In this article, we identified a novel mechanistic role of both BER and MMR pathways in mediating cellular responses to cisplatin treatment. Cells defective in BER or MMR display a cisplatin-resistant phenotype. Targeting both BER and MMR...
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تاریخ انتشار 2011